On top, molecular-targeted agents are increasingly administered. Understanding how the parasites create the haemozoin molecule and the disruption of its creation aids in the development of drugs to combat this disease.Įach year more than 450,000 Germans are expected to be diagnosed with cancer subsequently receiving standard multimodal therapies including surgery, chemotherapy and radiotherapy. Sequestration of the toxic haem resulting from haemoglobin digestion is key for the parasites' survival and the focus of almost all existing anti-malarial drugs. Parasite growth in the presence of a static magnetic field appears to aid parasite growth. At 10 Hz the schizont life stage was most affected by the rotating magnetic fields (p = 0.0075) as compared to a static magnetic field of the same strength. The numbers of parasites were counted over the course of one intraerythrocytic life cycle via flow cytometry. Plasmodium falciparum cultures of different stages of intraerythrocytic growth (rings, trophozoites, and schizonts) were exposed to a magnetic field of 0.46 T at frequencies of 0 Hz (static), 1, 5, and 10 Hz for 48 h. Paramagnetic haemozoin crystals, a byproduct of the parasite's haemoglobin digestion, interact with a rotating magnetic field, which prevents their complete formation, causing the accumulation of free haem, which is lethal to the parasites. This study sought to investigate the paramagnetic nature of the parasite's haemozoin to inhibit parasite viability.

Increasing knowledge of the parasite life cycle and mechanism of infection may provide new models for improved treatment paradigms. Plasmodium falciparum is the deadliest strain of malaria and the mortality rate is increasing because of pathogen drug resistance.

Rife vs tens